Immunoadsorption of LPS, C5a and IL-6 in Severe Sepsis and Septic Shock (ISASS-1)

Charite University, Berlin, Germany

Overview

The purpose of this study is to determine whether immunoadsorption of LPS, Il-6 and C5a reduces systemic hyperinflammation, improves immune function and improves organ function in patients with severe sepsis and septic shock

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Septicemia

Interventions

Immunoadsorption of LPS, IL-6 and C5aPROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of severe sepsis or septic shock (ACCP/SCCM) * Presence of 4 SIRS criteria/indicators * Suspected or proven infection (refer also to: 1.) * Age 18-80 * APACHE II score \> 18 * At least one acute organ dysfunction (renal/pulmonary/hemodynamics/cerebral) Exclusion Criteria: * Suspected or proven pregnancy * Absolute contraindication for anticoagulation (active bleeding) * Absolute IgA-deficiency * History of anaphylactic reaction to egg-albumin * Participants in other clinical trials (\<12 wks. prior to study inclusion)

Locations (1)

Charite University Medicine Berlin

Berlin, State of Berlin, Germany

Data from ClinicalTrials.gov

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