Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion

Hospices Civils de Lyon200 enrolled

Overview

Propofol is a popular intravenous drug to induce anesthesia but it causes local pain with an incidence between 40 and 90%. Three different strategies to prevent propofol induced pain will be studied compared with placebo. Pain will be scored with a four-point scale.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

200

Conditions

Induction of Total Intravenous General Anesthesia

Interventions

kétamine 20mgDRUG

ephedrine 3mgDRUG

lidocaine 40mgDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: Healthy adults (ASA 1-2) for scheduled surgery under general anesthesia with propofol Exclusion Criteria: * pregnant * sedative or analgesic drug 24h before surgery * allergy with drug used in the study * difficulty of communication * absence of informed written consent

Locations (1)

Grégoire CHATAIN

Lyon, France

Outcomes

Primary Outcomes

After prophylactic solution, evaluation of the pain caused by injection of propofol with a four-point scale before lose of consciousness

Secondary Outcomes

Explicite and implicite memory of pain immediately after surgery and on day one

Adverse effects

Data from ClinicalTrials.gov

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