This study is a comparison between two commonly used antibiotics (Cefdinir vs. Amoxicillin/Clavulanate) in patients with acute sinus infection, surveying quality of life. The hypothesis is that the two treatments would be at the least equivalent based on clinical outcome measures of improvement in quality of life.
The purpose if this investigation is to evaluate the rate of improvement ub Quality of LIfe (QOL) in two different medications, a 10-day course of Cefdinir 300 mg PO BID versus a 10-day course of Amoxicillin/Clavulanate 1000 mg/62.5 mg XR BID, in the treatment of acute bacterial sinusitis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
100
cefdinir 300mg per orally twice daily for 10 days
1000mg /62.5mg extended release per orally twice daily for 10 days
University of Chicago
Chicago, Illinois, United States
Improvement in quality of life
Time frame: At baseline and within 1 week of completing treatment
SNOT 20 questionnaire
Time frame: At baseline and within 1 week of completing treatment
Clinical signs and symptoms alleviated
Time frame: At baseline and within 1 week of completing treatment
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