Low-dose Hydrocortisone in Acutely Burned Patients

Hospices Civils de Lyon40 enrolled

Overview

Major burns trigger the release of circulating mediators, as cytokines and endotoxin that induces a systemic inflammatory response syndrome. The cardiovascular effects are similar to those seen in septic shock. After the initial hypovolemic phase, patients with extensive burns often present a shock with increased cardiac output and reduced systemic vascular resistances. As described in septic shock, we test the hypothesis that low-dose hydrocortisone could decrease the duration of the shock period.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

Conditions

Burns

Interventions

hydrocortisone 200 mg/dayDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * males and females, * between 18 and 75 year old * who present a burned surface more than 30% of the body surface * who need catecholamine infusion * between J0 and J3 after the injury. Exclusion Criteria: * pregnancy, * trauma, * sepsis, * cardiac insufficiency, * AIDS, * etomidate administration

Locations (1)

Sylvie TISSOT

Lyon, France

Outcomes

Primary Outcomes

Number of patients who do not receive any more catecholamine 4 days after the beginning of the shock

Secondary Outcomes

Duration of catecholamine administration

Doses of administered catecholamine

Adrenal insufficiency incidence

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.