Phytosterol Supplementation and Cardiovascular Risk

The Cooper Institute72 enrolled

Overview

This study examined the effects of 2.6 g/d of phytosterol ingestion on LDL cholesterol metabolism. It is expected that this dose will significantly reduce LDL cholesterol after 12 weeks of supplementation. The study recruited 72 men and women 20-70 years of age with mild hypercholesteremia (\>130 mg/dl LDL-C). They were assigned to 1 of 2 groups. Participants ingested the supplement or a placebo for 12 weeks, with an interim assessment at 6 weeks. Participants agreed to maintain current diet, medication, and exercise habits and to not donate blood during the trial.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Hypercholesteremia

Interventions

phytosterolDRUG

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * mild hypercholesteremia, sign informed consent, not donate blood, maintain diet and exercise habits Exclusion Criteria: * BMI \<18.5 or \>34.9, recent blood donation, serious or life-threatening disease

Locations (1)

The Cooper Institute

Dallas, Texas, United States

Outcomes

Primary Outcomes

Ingestion of the supplement will result in reduced LDL cholesterol.

Data from ClinicalTrials.gov

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