Edaravone and Argatroban Stroke Therapy Study for Acute Ischemic Stroke

Inclusion Criteria: * Acute ischemic stroke \< 24 hours of onset * Measurable neurological deficits caused by the present attack, ranging from 1 to 22 of NIHSS score on admission Exclusion Criteria: * Definite or possible cardiogenic brain infarction * Definite lacunar infarction * Prior ischemic stroke within 6 months * Evidence of hemorrhagic brain infarction, epidural hematoma, intracerebral hematoma, or intraventricular hemorrhage * Severe consciousness disturbances (semicoma to deep coma) * Neurological signs clearing spontaneously * Disability of 2 or more on mRS score before the index stroke aPTT being out of the normal range or 1.5 times longer than the pretreatment value * If taking an oral anticoagulant, INR being 1.6 or more, or no INR data * Treatment with urokinase, t-PA, heparin, ozagrel sodium, warfarin, or antiplatelet except for aspirin before enrollment * Intravascular surgery, surgical operation, hyperbaric oxygen therapy, or hypothermia therapy before enrollment * Serum creatinine \>1.5 mg/dL * Severe hepatic or cardiac disorders, infectious disorders, dehydration, etc. * Neoplasm * Pregnancy * Hypersensitivity to test drugs