Interaction Between Nalbuphine and Morphine in PCA

National Taiwan University Hospital200 enrolled

Overview

1. Nalbuphine is opioid mu receptor antagonist and kappa receptor agonist 2. This study was designed to investigate the interaction between nalbuphine and morphine

1. Nalbuphine is opioid mu receptor antagonist and kappa receptor agonist 2. This study was designed to investigate the interaction between nalbuphine and morphine 3. The analgesic effect and opioid-related side effects will be investigated

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

200

Conditions

Postoperative Pain

Interventions

Nalbuphine and morphineDRUG

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age 18-65 y/o 2. Female patients of ASA physical status I to III 3. Scheduled for elective abdominal hysterectomy, myomectomy, or excision of ovarian tumor Exclusion Criteria: 1. Patients with a definite diagnosis of chronic pain syndrome, psychiatric disorders, or drug abuse (include opioids, NSAIDs, sedatives, antidepressants) 2. Intraoperative fentanyl use \> 3 μg/kg 3. Patients with definite diagnosis of esophageal reflux syndrome 4. Use of sedatives, antiemetics, or antipruritics within 24 hours before operation 5. Surgery \> 4 hours or laparoscopy surgery

Locations (1)

National Taiwan University Hospital

Taipei, Taiwan

RECRUITING

Outcomes

Primary Outcomes

analgesic effect

Secondary Outcomes

incidence of opioid-related side effects

Data from ClinicalTrials.gov

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