Skeletal Muscle Dysfunction in Heart Failure

Ullevaal University Hospital45 enrolled

Overview

Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart. We hypothesize that congestive heart failure has systemic effects that causes the skeletal muscle dysfunction.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

ECT

Masking

SINGLE

Enrollment

Conditions

Heart Failure, Congestive

Interventions

One-knee extension ergometerBEHAVIORAL

Eligibility

Sex: ALLMin age: 40 YearsMax age: 78 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Coronary Heart Failure * Ejection fraction \<35% * NYHA 2-3 * Spirometry FEV1 \> 80% Exclusion Criteria: * Cardiomyopathy * Transplantation candidate * Active malignancy * Restraining skeletal-muscular disease * Claudication in legs * Hospitalized last 30 days due to acute ischemic episode * Intravenous inotrope or vasodilatating drugs last 14 days prior to inclusion * AMI last 8 weeks prior to inclusion * Organized training last 4 months * Smoking on daily basis last 4 months * Creatinin \< 150microliters/liter

Locations (2)

Institute for Experimental Medical Research

Oslo, Oslo, Norway

RECRUITING

Norwegian School of Sport Sciences

Oslo, Oslo, Norway

RECRUITING

Data from ClinicalTrials.gov

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