Effects of Vitamin D Supplementation on Antimycobacterial Immunity

Barts & The London NHS Trust230 enrolled

Overview

The purpose of this study is to determine how vitamin D supplementation (ergocalciferol) affects the immune response to mycobacterial infection.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

230

Conditions

Tuberculosis

Interventions

ErgocalciferolDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult * Tuberculosis (TB) contact or TB patient Exclusion Criteria: * Pregnancy * Breastfeeding * Hyperparathyroidism * Sarcoidosis * Renal failure * HIV infection

Locations (1)

Tuberculosis Clinic, Newham Chest Clinic

London, United Kingdom

Outcomes

Primary Outcomes

Bacillus Calmette-Guerin (BCG) lux whole blood assay

Secondary Outcomes

Antigen-stimulated whole blood interferon gamma production

Data from ClinicalTrials.gov

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