Right ventricular apical pacing in patients treated with a pacemaker is unnecessary in cases where patients have stable atrioventricular (AV)-conduction. Recent findings demonstrate that pacing even might have unfavourable effects, especially if patients suffer from additional cardiac diseases such as heart failure. The Search AV+ algorithm was designed to avoid ventricular pacing and support intrinsic AV-conduction in order to avoid possible detrimental effects of right ventricular apical pacing. The goal of the EnTRINSIC study is to assess the amount of ventricular stimulation, the amount of hospitalizations, the occurrence of atrial fibrillation and the usage of drugs in patients treated with pacemakers with an activated Search AV+ algorithm versus patients treated with an individual optimization of the pacemaker settings to minimize the amount of right ventricular pacing.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
135
Klinikum Großhadern Herzchirurgische Klinik und Poliklinik
Munich, Bavaria, Germany
Internistische Praxis Dr. Med. Schade
Berlin, Germany
St. Josefs Hospital
Bochum, Germany
Praxis Dr. Med. Markert
Gaggenau, Germany
Krankenhaus Martha Maria Halle
Halle, Germany
Universitätsklinikum Heidelberg
Heidelberg, Germany
St. Vincentius Kliniken
Karlsruhe, Germany
Vinzentius Krankenhaus
Landau, Germany
Klinikum der Johannes-Gutenberg-Universität
Mainz, Germany
Städtisches Klinikum Neunkirchen
Neunkirchen, Germany
...and 4 more locations
Amount of right ventricular pacing
Time frame: Baseline to 36 months post-implant
Change in intrinsic AV delay
Time frame: Baseline to 36 months post-implant
Hospitalizations because of symptomatic heart failure
Time frame: Baseline to 36 months post-implant
Hospitalizations because of symptomatic atrial fibrillation
Time frame: Baseline to 36 months post-implant
Medication
Time frame: Baseline to 36 months post-implant
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.