Rivastigmine For Methamphetamine Dependent Individuals

Inclusion Criteria: * Speaks English * Not seeking treatment for methamphetamine dependence at study entry * Meets DSM-IV criteria for methamphetamine abuse or dependence * Smokes or intravenously uses methamphetamine * Resting pulse between 50 and 90 beats per minute within 2 days prior to study entry * Systolic blood pressure between 85 and 150 mmHg and diastolic blood pressure between 45 and 90 mmHg within 2 days prior to study entry * Electrocardiogram demonstrating normal sinus rhythm, normal conduction, and no clinically significant arrhythmias * Medical history and brief physical examination demonstrating no clinically significant contraindications for study participation Exclusion Criteria: * History or evidence of seizures or brain injury * Previous adverse reaction to methamphetamine * Neurological or psychiatric disorders (e.g., psychosis, bipolar illness, or major depression) * Organic brain disease or dementia * History of any psychiatric disorder that requires ongoing treatment or that would make study compliance difficult * History of suicide attempts within the 3 months prior to study entry * Heart disease or high blood pressure * Family history of early cardiovascular morbidity or mortality * Untreated or unstable medical illness, including neuroendocrine, autoimmune, liver, kidney, or active infectious disease * HIV infected * AIDS-defining illness * Currently taking antiretroviral medication * Pregnant or breastfeeding * Unwilling to use an adequate method of contraception for the duration of the study * History of respiratory illness (e.g., asthma, chronic coughing, and wheezing) * Currently using alpha or beta agonists, theophylline, or other sympathomimetics