In the context of Sub-saharian Africa, this trial evaluate one of the most simple treatment available for HIV-1 infected patients. The combination proposed is a triple antiretroviral therapy with only one intake of 3 pills per day. This combination has already been studied in the North countries. Here in Senegal, the efficacy and the compliance to treatment will be evaluated after 24, 48 and 96 weeks of treatment.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
40
Centre de Traitement Ambulatoire, CHU de Fann
Dakar, Senegal
Service des Maladies Infectieuses, CHU de Fann
Dakar, Senegal
Evaluation of the antiretroviral efficacy as first line treatment assessed as percentage of patients with viral load below 400 copies/ml at week 48 in the intention to treat (ITT) population
Time frame: S48
Reduction of the viral load and percentage of patients with a viral load lower than 50 copies/ml
Time frame: S24 and S96
Viral load evolution
Time frame: S24 and S48
Genotype resistance profile evaluation failing patients
Time frame: S24, S48, S96
Immune benefits of the combination
Plasma concentrations of FTC, TDF and EFV
Time frame: S4
Adverse events clinic and lipids
Compliance
Time frame: S48 and S96
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