Study of the Treatment of Articular Repair (STAR)

Inclusion Criteria: * Provided written informed consent * Documented history of at least one Grade III or Grade IV defect (modified Outerbridge classification) on the medial or lateral femoral condyle or trochlea * Failed prior treatment for articular cartilage defects of the knee, e.g. inadequate response to a non- ACI surgical procedure to treat the lesion, within past 3 yrs * Patient reported overall knee condition of 5 or less on the Modified Cinn Rating System * patients must have had a cartilage defect located on the medial or lateral femoral condyle or trochlea which had an inadequate response to a prior arthroscopic or other non-Carticel surgical repair procedure Exclusion Criteria: * see above