This study was designed to evaluate if, in children with asthma, a stepwise treatment (five levels varying from once daily fluticasone propionate 100mcg until twice daily a fixed combination of salmeterol and fluticasone propionate 50/500 mcg) based on symptom scores alone results in a sub-optimal treatment when compared to treatment based on cumulative symptom scores and bronchial hyperresponsiveness (PD20 methacholine).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
200
GSK Investigational Site
Alkmaar, Netherlands
GSK Investigational Site
Almere Stad, Netherlands
GSK Investigational Site
Amsterdam, Netherlands
Asthma symptom free days during the last 12 weeks of the treatment period.
Bronchial hyperresponsiveness, determined by PD20 methacholine at the end of the study.
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GSK Investigational Site
Amsterdam, Netherlands
GSK Investigational Site
Breda, Netherlands
GSK Investigational Site
Eindhoven, Netherlands
GSK Investigational Site
Groningen, Netherlands
GSK Investigational Site
Hilversum, Netherlands
GSK Investigational Site
Leiden, Netherlands
GSK Investigational Site
Maastricht, Netherlands
...and 6 more locations