Trial of Pindolol Augmentation in Venlafaxine Treated Patients With Major Depression

Hillerod Hospital, Denmark31 enrolled

Overview

This study investigates the hypothesis that pindolol can accelerate the response to antidepressants in patients with major depression treated with venlafaxine.

Antidepressant therapy has a delayed onset of action of 4-6 weeks. Pindolol has in some studies shown an accelerating effect. In this study we investigate the effect of 20 mg of pindolol retarded formulation in combination with Venlafaxine compared to placebo Pindolol and Venlafaxine for a duration of 19 days. Effect is measured by the Hamilton Depression rating Scale and the Preskorn Scale (self-rating).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Major Depression

Interventions

Pindolol and venlafaxinDRUG

pindolol 20 mg and venlafaxin 150 mg

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Major depression Exclusion Criteria: * Allergy towards pindolol, venlafaxine or other tablet constituents * Liver or kidney impairment * Diabetics * Age below 18 years * Severe cardiac disease * Asthma.

Locations (1)

Psychiatric Research Unit, Hillerod Hospital

Hillerød, Denmark

Outcomes

Primary Outcomes

Hamilton Depression Rating Scale scores

Time frame: 1 week

Secondary Outcomes

Preskorn scores

Time frame: one day

Data from ClinicalTrials.gov

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