Metabolic Capacity of Israeli Populations

Hadassah Medical Organization1,200 enrolled

Overview

The ability to metabolize drugs varies greatly among individuals. Major fraction of this variability lies in genetic polymorphisms of genes encoding for enzymes responsible for both phase I and phase II reactions. The purpose of this study ws to evaluate the phenotypic activity and the frequency of genetic polymorphisms in different phase II and phase I enzymes among various populations residing in Israel.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

1,200

Conditions

Healthy Volunteers

Interventions

DebrisoquineDRUG

MephenytoinDRUG

DapsoneDRUG

CaffeineDRUG

Eligibility

Sex: ALLMin age: 20 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age range 20-50 * Absence of significant disease state Exclusion Criteria: * The presence of significant disease states * The regular use of drugs (including birth control pills)

Locations (1)

Hadassah Medical Organization

Jerusalem, Israel

RECRUITING

Outcomes

Primary Outcomes

Phenotypic measurements of various P450 and non-P450 enzymes involved in drug metabolism.

Time frame: 24 hours

Frequency of genetic polymorphisms in these enzymes among different Israeli populations.

Time frame: 24 hours

Central Contacts

Yoseph Caraco, MD

CONTACT

00 972 2 6778584 caraco@hadassah.org.il

Data from ClinicalTrials.gov

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