The Addition of Polychemotherapy to Adjuvant Radiotherapy in the Treatment of Non-Metastatic Uterine Sarcomas

Inclusion Criteria: * Histologically confirmed uterine sarcoma (rereading in reference centers) * Leiomyosarcoma, adenosarcoma, carcinosarcoma and high grade endometrial stromal sarcoma * All stages \<= stage III (FIGO modified for endometrial carcinoma) * Full surgical exeresis * Age \>= 18 years and physiological age \<= 65 years * Negative extension check-up (thoracic and abdomino-pelvic TDM) * Performance status (PS) \<= 2 (ECOG) * Normal haematologic functions (absolute neutrophil count \> 1,500/mm3, platelets \> 100,000/mm3) * Serum creatinine \< 1.25 x ULN * Good hepatic check-up (total serum bilirubin \< 1.5 x ULN; AST or ALT \< 2.5 x ULN) * Absence of neuropathy \> grade 1 * Left ventricular ejection fraction \> 50% (by isotopic or ultrasound scan determination) * Written informed consent Exclusion Criteria: * Low grade endometrial stromal sarcoma * Time since surgery \> 8 weeks * Specific contraindications to the studied treatment (cardiac, kidney, or hepatic ones) * Antecedents or evolutive psychiatric disorder * Concurrent active infection or other serious uncontrolled systemic disease * Antecedents of cancer but a cutaneous basocellular one or an in situ epithelioma of the cervix