Efficacy and Effectiveness of Combined Therapy for Uncomplicated Malaria Treatment in Peru

Inclusion Criteria: * Age \> 1 year * Axillary temperature ≥ 37.5ºC and/or history of fever in the previous 48 hours without any other evident cause * Unmixed infection with P. falciparum of between 250 and 100,000 asexual parasites/mm3 as determined by microscopic exam of the thick or thin smear * An informed consent obtained from the patient or his/her guardian (in case of patients ≤ 18 years old) and assent for children (8-18 years old) * Willingness to come to the health facility for the following 28 days Exclusion Criteria: * Signs or symptoms of severe malaria * Other severe chronic diseases (e.g., cardiologic, renal, or hepatic diseases; HIV/AIDS; severe malnutrition) * History of allergy to any of the proposed treatment or its alternatives, i.e. mefloquine, artesunate, quinine, tetracycline, or clindamycin * Pregnancy (based on urine test), since this group of patients receives other drugs for malaria treatment in accordance with Peruvian national guidelines.