The aim of study is to evaluate whether Doppler ultrasound can accurately identify patients who are at risk of recurrent bleeding, who will require endoscopic therapy, and who will fail endoscopic therapy.
Bleeding peptic ulcer is a life-threatening emergency. Endoscopic therapy is a proven technique in the acute hemostasis of bleeding ulcers. Currently there is no objective assessment of adequacy of endoscopic therapy. Endoscopic Doppler ultrasound enables endoscopists in detecting blood flow in a vessel beneath an ulcer. A persistent signal after endoscopic therapy predicts recurrent bleeding. The current study proposes to compare assessment of ulcer base using either Doppler ultrasound or endoscopists' interpretation of ulcer floors. The trial design is one of a prospective randomized controlled cross-over study in which patients with severe upper gastrointestinal bleeding and documented peptic ulcers at endoscopy are enrolled.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
121
Applying to ulcer base to assess the blood flow underneath the ulcer
Endoscopy Center, Prince of Wales Hospital
Hong Kong SAR, China
Recurrent bleeding
Time frame: Within 30 days
Length of stay
Time frame: Within 56 days
ICU utilization
Time frame: Within 56 days
Blood Transfusion during hospital
Time frame: Within 56 days
Need for urgent/emergent ulcer surgery for bleeding
Time frame: Within 56 days
Need for angiographic treatment of bleeding
Time frame: Within 56 days
Death
Time frame: within 56 days
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