Cobalt Chromium Stent With Antiproliferative for Restenosis II Trial (COSTAR II)

Inclusion Criteria: General Inclusion Criteria: * Eligible for percutaneous coronary intervention (PCI) * Documented stable or unstable angina pectoris (Class I, II, III or IV), documented ischemia, or documented silent ischemia * Documented LVEF ≥25% within the last 6 weeks. * Eligible for coronary artery bypass graft surgery (CABG) Exclusion Criteria: General Exclusion Criteria: * Known sensitivity to paclitaxel or polymeric matrices: Translute or PLGA. * Planned treatment with any other PCI device in the target vessel(s). * MI within 72 hours prior to the index procedure * Patient is in cardiogenic shock * Cerebrovascular Accident (CVA) within the past 6 months * Acute or chronic renal dysfunction (creatinine \>2.0 mg/dl or \>150 µmol/L) * Contraindication to ASA or to clopidogrel * Thrombocytopenia * Active GI bleeding within past three months * Known allergy to stainless steel or cobalt chromium * Any prior true anaphylactic reaction to contrast agents * Patient is currently taking colchicine