MRI-guided Bone Marrow Biopsies of Prostate Cancer Patients

Dana-Farber Cancer Institute20 enrolled

Overview

The purpose of this study is to target lesions of the prostate in the bone and to biopsy these lesions using MRI to identify the areas.

* This study involves a one-time, MRI-guided bone marrow biopsy. Prior to this procedure, patients will need to have a bone scan performed within the last three months and a PSA blood test drawn within one month of registration to the study. * Patients are also required to participate in the DFCI research study "Collection of Specimens and Clinical Data for Patients with Prostate Cancer or at High Risk for Prostate Cancer".

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Prostate Cancer

Interventions

Magnetic Resonance ImagingPROCEDURE

Bone Marrow BiopsyPROCEDURE

Eligibility

Sex: MALEMin age: 30 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Histologic diagnosis of prostate cancer * Bone scan consistent with or suspicious of metastatic prostate cancer within last three months * Platelet count \> 50,000/ul * PT and aPTT \< 1.5 x control * At least one week removed from taking aspirin or coumadin * Currently participating in protocol "Collection of Specimens and Clinical Data for Patients with Prostate Cancer or at High Risk for Prostate Cancer" Exclusion Criteria: * Devices incompatible to MR studies (e.g. pacemakers, ear implants, etc.)

Locations (1)

Dana-Farber Cancer Institute

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

To compare the yield of detecting metastatic prostate cancer tissue using MRI-guided bone marrow needle biopsies to that of historical controls obtained through unguided biopsies.

Secondary Outcomes

To evaluate the sensitivity of radiographic bone marrow changes detected by MRI for prostate cancer, as determined by the pathologic findings from bone marrow biopsy.

Data from ClinicalTrials.gov

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