The purpose of this study is to determine if the use of breast MRI in detecting breast malignancies in survivors of Hodgkin's disease is more successful than the traditional mammogram.
* The screening breast MRI and mammography will be performed 6 months or longer after the last mammogram. For pre-menopausal women, the screening will be performed during the second week of the menstrual cycle to reduce cycle-related breast changes. As much as possible, the breast MRI and mammogram are to be performed on the same day. * On the day of the breast imaging studies, the patient will also be asked to fill out a baseline breast health questionnaire, which includes questions on time since radiation therapy, prior screening history, history of prior benign breast biopsies, menopausal status, prior hormonal therapy use, etc. * In patients with suspicious findings or findings highly suggestive of malignancy, the abnormal findings will be reviewed with the patient and recommendations will be made for a biopsy.
Study Type
OBSERVATIONAL
Enrollment
148
Repeated once a year for three years
Repeated once a year for three years
Brigham and Women's Hospital
Boston, Massachusetts, United States
Dana-Farber Cancer Center
Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
To compare the sensitivity, specificity, positive and negative predictive value of mammography and breast MRI for breast cancer detection in women treated for Hodgkin's disease.
Time frame: 5 years
To describe the MRI appearance and enhancing characteristics of breast cancer after Hodgkin's disease
Time frame: 5 years
to correlate the breast MRI findings and pathological findings
Time frame: 5 years
to determine the incidence of interval breast cancer in the screened population.
Time frame: 5 years
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