Genotoxicity Assessment for Patients Undergoing Radiation Treatment

Yuhchyau Chen47 enrolled

Overview

The purpose of the research study is to evaluate an automated, laser-based technique for measuring DNA damage caused by radiation during cancer treatment in immature red blood cells.

Correlative studies: analysis of RT effect on genotoxicity by assessing cytogenetic changes (dicentrics), micronucleated lymphocytes (MN-lymph), and micronucleated reticulocytes (MN-RET) using peripheral blood of patients receiving radiation. i) document the kinetics by which radiation-induced MN-RET enter the peripheral blood stream. ii) benchmark the MN-RET endpoint against current gold-standard biodosimetry endpoints-dicentrics and MN-lymphocytes. iii) measure inter-individual variation in baseline and radiation-induced MN-RET frequencies. iv) in collaboration with several FCM-equipped laboratories, evaluate the transferability of the human MN-RET scoring assay.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Neoplasms

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients that are scheduled to begin radiotherapy to the large-field chest region are eligible if: * Daily radiation dose is between 1.8 and 5 Gy/day * Any single dimension of field size is ≥ 15 cm * Provision of written informed consent or * Or patients receiving IMRT or Tomotherapy, when low-dose radiation is spread out to the normal tissues, irrespective of daily radiation doses. * Or patients receiving radionucleotides as part of the medical treatment (cancer or non-malignant conditions) * Or patients who will receive diagnostic CT scans, PET/CT scans, mammograms, or diagnostic imaging requiring radionucleotides

Locations (1)

University of Rochester, Dept. Radiation Oncology

Rochester, New York, United States

Outcomes

Primary Outcomes

Measure the Change in MN-RET in the blood

Time frame: Baseline and 1 day

Data from ClinicalTrials.gov

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