Efficacy and Safety of DHEA for Myotonic Dystrophy

Inclusion Criteria: * Myotonic dystrophy (genetically proven) * MDRS score of 3 or 4 Exclusion Criteria: * Age \<18 years or \>70 years * Pregnancy or breastfeeding * Poor compliance to treatment and follow up * Inclusion in any other clinical trial * Severe cardiac disease: acute myocardial infarction in the preceding 6 months, unstable heart failure, uncontrolled hypertension (systolic blood pressure \>180 mmHg or diastolic blood pressure \>100 mmHg after 10 minutes of rest in the lying position), severe arteritis, any past history of thrombose or embolic event, any past history of symptomatic arrhythmia) * Chronic renal failure * Chronic liver disease * Long term mechanical ventilation * Any ongoing cancer * Any underlying endocrine disorders * Impaired swallowing * Previous treatment with DHEA