The purpose of this study is to determine whether early mechanical ventilation can prevent hospital acquired pneumonia in adults with Guillain Barré Syndrome.
Hospital acquired pneumonia is a common and severe complication of Guillain Barré Syndrome. Several factors have been recognized as predictors of respiratory failure in adults with Guillain Barré Syndrome. They include a time from disease onset and patient admission of less seven days, inability to lift head, impaired swallowing and a forced vital capacity of less than 60% of predictive value. We reasonned that early mechanical ventilation may prevent aspiration which is likely the main cause of pneumonia in these patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
50
Non invasive mechanical ventilation at least 6 hours per day - if difficult swallowing, tracheal intubation and invasive mechanical ventilation
oxygen will be delivered via facial mask whenever needed and physiotherapy
Raymond Poincaré Hospital
Garches, France
Rate of hospital acquired pneumonia from randomization to study day 90
Time frame: Day 90
Time on a ventilator
Time frame: Day 90
Intensive care unit lenght of stay
Time frame: Day 90
Hospital length of stay
Time frame: Day 90
Tolerance
Time frame: Day 90
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