The purpose of this study is to determine whether Campath-1H induction and the associated lymphocyte depletion will permit long-term rejection-free renal allograft survival in the absence of ongoing corticosteroid administration.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
33
two intravenous 20mg/m2/doses, the first on the day of transplant and the second dose on day 1 post transplant
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, United States
Incidence of Graft Rejection
Time frame: at 1, 3, 6, 12, and 24 months
Participant Graft Survival
Time frame: at 6, 12, and 24 months
Estimated Glomerular Filtration Rate (EGFR)
Measure of renal function
Time frame: at 1, 6, 12 and 24 months
Number of Participants With Infection
Cytomegalovirus(CMV), Epstein Barr Virus (EBV) BK Virus (BK)
Time frame: up to 24 months
Number of Participants With Malignancy
Time frame: up to 24 months
Growth Post-transplant Reported by Height Z Score
A z-score (aka, a standard score) indicates how many standard deviations an element is from the mean, in this case, height. A score of '0' is equal to the mean, a score less than 0 is less than the mean, and a score greater than 0 is greater than the mean.
Time frame: up to 24 months
Number of Participants With Hypertension
Time frame: up to 24 months
Number of Participants With Hyperlipidemia
Time frame: up to 24 months
Participant Survival
Time frame: at 6, 12, and 24 months
Number of Participant With Diabetes Mellitus
Time frame: up to 24 months
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