Xerostomia in Head and Neck Cancer Patients Receiving Radiation as the Primary Treatment Versus Patients Who Will Not Have Such a Procedure

AHS Cancer Control Alberta42 enrolled

Overview

The purpose of this study is to compare the side effects of radiation treatment and surgery versus radiation alone, where no surgery is done to move the salivary gland and place it under the chin region where it can be shielded from radiation.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Head and Neck Cancer

Interventions

radiation treatment and surgeryPROCEDURE

radiation alonePROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with a histological diagnosis of squamous cell carcinoma * Patients with unilateral or no neck involvement of the nasopharynx * The submandibular transfer will be done on the uninvolved side of the neck. * Karnofsky score greater than or equal to 70 * Expected survival greater than one year * A signed informed consent Exclusion Criteria: * Bilateral neck nodes involvement. Involvement of level 1 lymph nodes on the side of the proposed procedure.

Locations (1)

Cross Cancer Institute

Edmonton, Alberta, Canada

Outcomes

Primary Outcomes

Quality of life

Secondary Outcomes

Treatment interruptions

Incidence of percutaneous endoscopic gastronomy (PEG)

Incidence of oral candidiasis

Overall survival

Disease free survival

Pattern of recurrence

Complications

Data from ClinicalTrials.gov

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