Intermittent Antimalaria Treatment With SP in African Children

Charite University, Berlin, Germany1,200 enrolled

Overview

\- intermittent preventive treatment with SP in children to evaluate efficacy and safety of this drug combination in children in northern Ghana

* Sulfadoxine and pyrimethamine have long been used for malaria prevention and treatment. In this study, following suggestions of WHO, these drugs are used for intermittent treatment. * It will be tested if this approach reduces the number of malaria attacks and ameliorates the severity of the disease * It will also be determined if anemia due to malaria, which is prevalent in northern Ghana, may be reduced * Moreover, the interaction between red cell polymorphisms such as HbS, HbC, alpha-thalassemia and glucose-6-phosphate dehydrogenase deficiency and SP will be examined

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

1,200

Conditions

Malaria Anemia

Interventions

Sulfadoxin (12.5) Pyrimethamine (250 mg)DRUG

Eligibility

Sex: ALLMin age: 2 MonthsMax age: 4 MonthsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * informed consent by parents or guardian * no concomitant serious disease * age \>2 months Exclusion Criteria: * serious allergy or hypersensitivity to sulfonamides or pyrimethamine * no severe hepatic or renal dysfunction * serious breach of study protocol

Outcomes

Primary Outcomes

Efficacy and safety of IPTi with SP

Impact of IPTi on incidence on malaria attacks

Impact of IPTi on anemia

Secondary Outcomes

Interaction between erythrocyte polymorphisms and SP

Influence on parasite multiplicity

Impact on child development

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.