Alcoholism and Schizophrenia: Effects of Clozapine

Inclusion Criteria: * Diagnosis of schizophrenia or schizoaffective disorder * Current diagnosis of an alcohol use disorder with active use in the last 30 days. * The participant (or the participant's authorized legal representative) understands the nature of the study and has he/she signed an informed consent. * Ages 19-65. * Taking olanzapine, risperidone, quetiapine or a typical antipsychotic agent for at least 8 weeks prior to study randomization * If taking depot medication, at least 3 injection cycles since the last injection prior to study randomization. Exclusion Criteria: * Contraindication to clozapine * Women who are currently pregnant or who desire to become pregnant during the course of the study. * Current and past treatment with clozapine * Current treatment with agents proposed to curtail substance use (e.g., disulfiram, naltrexone, acamprosate, buspirone) and agents contraindicated for use with clozapine (e.g., inderal, tegretol, lithium). * Meets DSM-IV criteria for current dependence of substances other than alcohol.