The Medtronic InSync III Marquis Cardiac Resynchronization Therapy Defibrillator (CRT-D)-System (implantable cardioverter-defibrillator with biventricular stimulation for cardiac resynchronization) is equipped with the "Conducted-Atrial Fibrillation (AF)-Response-Algorithm (CAFR)". This algorithm is designed to maximize biventricular stimulation and thus the amount of cardiac resynchronization when atrial fibrillation occurs. The goal of the study is the evaluation of the effect of the CAFR in CRT-patients suffering from atrial fibrillation by quantification of the increase of biventricular pacing during atrial fibrillation caused by CAFR as well as the influence of the CAFR on the ventricular heart rate.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
100
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Universitätsklinikum Aachen
Aachen, Germany
Berufsgenossenschaftliche Kliniken Bergmannsheil
Bochum, Germany
Evangelisches und Johanniter Klinikum Duisburg / Dinslaken / Oberhausen GmbH
Duisburg, Germany
Klinikum der Justus-Liebig-Universität
Giessen, Germany
Medizinische Hochschule Hannover
Hanover, Germany
Marien-Hospital Herne
Herne, Germany
Klinikum Siegburg Rhein-Sieg GmbH Krankenhaus und Herzzentrum Siegburg
Siegburg, Germany
Amount of biventricular pacing in ON-group compared to OFF-group
Time frame: 1 month post-implant to 12 months post-implant
Influence of the conducted AF response algorithm on the ventricular heart rate during atrial fibrillation
Time frame: 1 month post-implant to 12 months post-implant
Amount of patients who will be free from AF during the study
Time frame: Implant to 12 months post-implant
Amount of hospitalizations due to heart failure (amount and duration in days)
Time frame: Implant to 12 months post-implant
Occurrence and evaluation of rhythm disturbances: atrial arrhythmias (atrial tachyarrhythmia [AT]/AF episodes [h/day])
Time frame: Implant to 12 months post-implant
Occurrence and evaluation of rhythm disturbances: ventricular arrhythmias
Time frame: Implant to 12 months post-implant
Characterization of the heart failure (HF)-patient population by means of: echocardiography [left ventricular ejection fraction (LVEF [%])
Time frame: Implant to 12 months post-implant
Characterization of the heart failure (HF)-patient population by means of: left ventricular end diastolic diameter (LVEDD [mm])
Time frame: Implant to 12 months post-implant
Characterization of the heart failure (HF)-patient population by means of: left ventricular end systolic diameter (LVESD [mm])
Time frame: Implant to 12 months post-implant
Characterization of the heart failure (HF)-patient population by means of: left atrial end diastolic diameter (LAEDD [mm])]
Time frame: Implant to 12 months post-implant
Characterization of the heart failure (HF)-patient population by means of: New York Heart Association (NYHA) classification
Time frame: Implant to 12 months post-implant
Characterization of the heart failure (HF)-patient population by means of: 6-minute walk test
Time frame: Implant to 12 months post-implant
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