Therapy With Topotecan and Carboplatin by Patients With Relapsed Ovarian Cancer

Inclusion Criteria: * Age \>= 18 years * patient with ovarian cancer after primary therapy * bone marrow function leukocytes \>= 4,0 x 109/ l, platelets \>= 100 109/l, hemoglobin \>= 9 g/dl * renal function creatinin \<= 1,5 mg% or creatinin clearance \>= 60 ml/min * liver function bilirubin \<= 2,0 mg/dl, SGOT, SGPT and AP within 3 fold of the reference laboratory's normal range * ECOG \<= 2 * Intention of regular follow-up visits for the duration of the study * written informed consent Exclusion Criteria: * any known hypersensitivity against topotecan isomerase-I-inhibitor other medication included in the study protocol * ECOG \> 2 * patients with radiotherapy within the last 4 weeks