To evaluate the efficacy of valsartan 160 mg/HCTZ 25 mg in patients not adequately responding to monotherapy with olmesartan medoxomil 40 mg or combination therapy with olmesartan medoxomil 20 mg plus HCTZ 12.5 mg by testing the hypothesis that valsartan 160 mg/HCTZ 25 mg significantly reduces the trough mean sitting diastolic blood pressure (MSDBP) after a 4-week treatment in the nonresponder population.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
212
Unnamed facility
Multiple Locations, Germany
Novartis Pharmaceuticals
Basel, Switzerland
Change from baseline in diastolic blood pressure after 4 weeks
Change from baseline in systolic blood pressure after 4 weeks
Diastolic blood pressure less than 90 mmHg after 4 weeks
Diastolic blood pressure less than 90 mmHg or decrease in diastolic blood pressure of 10 mmHg or greater after 4 weeks
Change from baseline heart rate after 4 weeks
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