Can Intravenous Vitamin C Improve Skin Hyperpigmentation in Long-Term Hemodialysis Patients?

National Taiwan University Hospital40 enrolled

Overview

Intravenous vitamin C may improve skin hyperpigmentation in chronic hemodialysis patients

Melanogenesis is caused by enzymatic conversion of tyrosine to melanin pigments.Ascorbic acid has the ability to inhibit peroxidase and may thus inhibit melanin synthesis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Kidney Failure, Chronic

Interventions

vitamin C, intravenous injectionDRUG

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * chronic hemodialysis patients Exclusion Criteria: * allergic to vitamin C, using steroid, etc

Locations (1)

National Taiwan University Hospital

Taipei, Taiwan

Outcomes

Primary Outcomes

Skin pigmentation extent

Secondary Outcomes

blood anti-oxidant level

Data from ClinicalTrials.gov

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