Gemcitabine and Ifosfamide As a Second-Line Systemic Chemotherapy for Cisplatin -Failed Advanced TCC

Inclusion Criteria: * Histologically or cytologically confirmed transitional cell carcinoma * Advanced / metastatic disease failed to prior chemotherapy (diagnostically confirmed disease progression during the treatment of last chemotherapy or within 6 months after the end of last chemotherapy) * Presence of at least one measurable disease which is defined as lesion that can be measured in at least 1 dimension as ³ 20 mm with conventional technique or ³ 10 mm with spiral CT scan * Performance status of ECOG 0, 1, 2 * Age 20 years or older * Life expectancy more than 3 months * Adequate hematopoietic function as defined below: * WBC ³ 3,000/uL * Platelets ³ 75,000/Ul * Adequate organ function as defined below: * Total bilirubin £ 1.5 ´ ULN * ALT / AST£ 5 ´ ULN * Creatinine £ 1.5 mg/dL * Adequate serum electrolyte concentration: * 4 mmol/L\<\[K+\] \<5.3 mmol/L * 0.74 mmol/L\<\[Mg2+\] \<1.03 mmol/ * 2.02 mmol/L\<\[Ca2+\]\<2.60 mmol/L * Result of ECG assessment: QTC \< 460 msec * Ability to understand and the willingness to sign a written informed consent document Exclusion Criteria: * Received chemotherapy, radiotherapy, surgery, or other investigational drug within 4weeks prior to entering the study * Receiving other concurrent palliative chemotherapy, radiotherapy, hormonal therapy, or other investigational drug except non-disease related conditions (e.g. insulin for diabetes) during study period * Presence of CNS metastasis * Previous or current malignancy with the exception of curatively treated non- melanoma skin cancer or cervical carcinoma in situ * Presence of serious concomitant illness which might be aggravated by study medication: 1. Uncontrolled infection (active serious infections that are not controlled by antibiotics) 2. Peripheral neuropathy grade 2 or higher (by NCI common toxicity criteria in sensory or motor neuropathy) 3. Clinically significant arrhythmia (electrocardiogram QTc greater than 500 msec) 4. Prior myocardial infarction or serious coronary arterial disease within the last 12 months * Mental status is not fit for clinical trial. * Women of child-bearing potential (pregnancy or breast feeding)