The Association of Endothelial Dysfunction and Cardiac Allograft Vasculopathy

National Taiwan University Hospital100 enrolled

Overview

Progressive cardiac allograft vasculopathy (CAV) is a serious complication in long-term survivors after heart transplantation. Therefore, we hypothesize that CAV is a diffuse and progressive process, and endothelial function may play an important role in predicting clinical outcome after heart transplantation. Therefore, this single-blinded study is designed to evaluate endothelial function, microvascular flow response and morphology of coronary artery in cardiac allografts, 1. The simultaneous use of IVUS and Doppler wire instrumentation in different pharmacological stress; 2. Tl-201 SPECT (dipyridamole stress/rest); to evaluate the correlation of endothelial function, coronary morphology change and Tl-201 dipyridamole stress myocardial perfusion image.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Heart Transplantation

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1\. Heart transplant receipients who undergoing the coronary angiographic follow-up as standard protocols. Exclusion Criteria: 1. Acute illness conditions including infection, congestive heart failure (NYHA Fc III, IV), etc. 2. Coronary angiographic finding: coronary stenosis\>30% (as grade III, IV by Klauss V et al, Am J Cardiol 1995; 76:463-6). 3. Creatinine \>3.0 mg/dl

Locations (1)

National Taiwan University Hospital

The Association of Endothelial Dysfunction and Cardiac Allograft Vasculopathy

Overview

Conditions

Eligibility

Locations (1)

Central Contacts