Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram. The investigators hypothesize that an infusion of saline + furosemide + mannitol will reduce rates of contrast-induced nephropathy when compared with saline infusion controls.
Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram. We hypothesize that an infusion of saline + furosemide + mannitol will reduce rates of contrast-induced nephropathy when compared with saline infusion controls. We define an episode of contrast nephropathy using the conventional often published definition of a 25% relative increase in serum creatinine OR a 44 umol absolute increase in serum creatinine within 48 hours of contrast exposure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
200
500 mls half-normal saline + 25g mannitol + 100 mg furosemide
500 mls half-normal saline
University of Alberta Hospitals
Edmonton, Alberta, Canada
Proportion of patients that develop contrast-induced nephropathy after cardiac angiography
Time frame: Within 48 hours of angiogram
Safety of the intervention based on transfer to ICU, need for dialysis, or death
Time frame: During hospitalization episode
Adverse clinical events and measures of renal function
Time frame: 6 weeks post-angiogram
Health related quality of life
Time frame: 6 weeks post-angiogram
Subgroup analyses based on (a) diabetes; (b) amount of contrast; and (c) baseline creatinine
Time frame: Within 48 hours of angiogram
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