A Randomized Controlled Trial of VSL#3 for the Prevention of Endoscopic Recurrence Following Surgery for Crohn's Disease.

Inclusion Criteria: 1. Subjects 16 years of age or older 2. Diagnosis of Crohn's disease 3. Resection of ileocolonic Crohn's disease and small bowel to colonic anastomosis within 30 days of randomization 4. Able to provide informed written consent 5. Women of child-bearing potential with a negative serum pregnancy test, and/or use of effective contraception Exclusion Criteria: 1. Use of perioperative steroids in tapering doses and anti-diarrheal agents 2. Treatment with a TNF-antagonist in the 8 weeks prior to resection 3. Clinically significant Crohn's disease elsewhere in the GI tract 4. Clinically documented short bowel syndrome 5. Serious disease other than Crohn's disease 6. Impaired liver or renal function 7. History of cancer with less than 2 years disease-free state 8. Abnormal Laboratory values 9. Alcohol or drug abuse 10. Some psychiatric conditions 11. Patients using other study medications 12. Patients who are unable to attend study visits or comply with study procedures 13. Positive pregnancy test