Investigation of Cognitive Function Before and After Induced Ventricular Fibrillation in Electrophysiological (EP) Study

Heidelberg University30 enrolled

Overview

In this study, changes in electroencephalogram (EEG) and the hemodynamic state during ventricular fibrillation or induced ventricular tachycardia are investigated.

Patients with a high risk of malignant tachyarrhythmia are routinely investigated by programmed electrophysiological study (EPS). To investigate the hemodynamic effects of ventricular arrhythmia to cerebral circulation an EEG and transcranial ultrasound are conducted simultaneously during the EPS. Before and after the EPS a neuropsychological test and an investigation of a specific blood sample (Neuron Specific Enolase, NSE) is done.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Ventricular Fibrillation Ventricular Tachycardia

Interventions

EEGDEVICE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 years * Positive agreement * EPS for primary and secondary prophylaxis of a malignant ventricular tachyarrhythmia: * primary prophylaxis: Brugada syndrome, long QT syndrome, cardiomyopathy, short QT syndrome * secondary prophylaxis: Multicenter Automatic Defibrillator Implantation Trial (MADIT) criteria, syncope, documented ventricular tachycardia Exclusion Criteria: * Severe neurological deficit * Cardiopulmonary resuscitation

Locations (1)

Fakultät für Klinische Medizin Mannheim Universitätsklinikum Mannheim der Ruprecht-Karls-Universität Heidelberg

Mannheim, Germany

RECRUITING

Central Contacts

Christian Wolpert, PD, MD

CONTACT

+49-621-383-2206 christian.wolpert@med.ma. uni-heidelberg.de

Data from ClinicalTrials.gov

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