The Effects of Curcuminoids on Aberrant Crypt Foci in the Human Colon

Inclusion Criteria: * Subjects must be eligible for colorectal cancer (CRC) screening/surveillance by current criteria. * Subjects must have at least 5 ACF on eligibility chromosigmoidoscopy examination. Exclusion Criteria: Subjects must not have: * Alcohol consumption of greater than 2 glasses of wine or beer per day or illicit recreational drug use * Platelet or coagulation abnormalities, or personal history of a bleeding disorder, including individuals taking warfarin. * High risk for developing endocarditis (history of endocarditis or rheumatic fever, cardiac valve prostheses, or mitral valve prolapse that requires antibiotic prophylaxis). * Uncontrolled hypertension, diabetes, or chronic congestive heart failure. * Renal insufficiency defined as a serum creatinine \> 2.5 mg/dl * History of colorectal surgery with removal of the distal 60 cm of colon or rectum. * History of other gastrointestinal mucosal epithelial diseases (such as Barrett's esophagus, chronic or recurrent peptic ulcer disease, celiac sprue or other disorders of nutrient absorption).