Improving Symptoms of Schizophrenia and Schizoaffective Disorder by Supplementing Medications With Pravastatin

Inclusion Criteria: * Diagnosis of schizophrenia or schizoaffective disorder * Male and female subjects; age 18-65 years inclusive * Ability to provide informed consent * No psychiatric hospitalization in the last 30 days prior to randomization * PANSS score at study entry between 80 and 120 inclusive, OR those who continue to experience some residual positive and/or negative symptoms and are not at their baseline level of functioning. * Current psychiatric medications stable for at least 30 days * Currently receiving only one antipsychotic medication * Female subjects of child-bearing age must use an acceptable method of birth control Exclusion Criteria: * Active, uncontrolled, or chronic liver disease * Heart failure * Current alcohol abuse or dependence * Female subjects who are pregnant, lactating or plan to become pregnant during the study period * History of allergic reaction with any statin in the past * Kidney disorder or other evidence of renal dysfunction * Uncontrolled diabetes * Untreated hyperlipidemia * Concurrently receiving treatment with cyclosporine, gemfibrozil, clofibrate, fenofibrate, niacin, macrolide antibiotics, erythromycin, HIV protease inhibitors, nefazodone, or verapamil