Radiation-Induced Cytokine Cascades and Their Correlation With Central Nervous System Injury

University of Rochester44 enrolled

Overview

Treatment for brain cancer may include radiation therapy. Radiation therapy is the treatment of tumors with X-rays. This study is related to understanding the side effects of radiation treatment for brain tumors. This study is being conducted by the University of Rochester Cancer Center to compare the extent of side effects of brain cancer treatment with changes in levels of blood proteins called cytokines.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Brain Neoplasm

Interventions

Radiation TherapyRADIATION

standard of care for the cancer being treated

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Any patient who will be treated to the brain or spinal axis for a CNS tum Patients so treated will be stratified according to whether or not the hypo is included in the treatment fields. * Patients receiving external beam radiation to the brain may also be rece chemotherapy or interferon-beta. (Add. #1, 11-9-95) * Patients receiving high dose rate (stereotactic radiosurgery) are eligible. * Patients must sign a study specific informed consent meeting all federal a guidelines. * Patients of any age, including children, are eligible (Add. #3, 11/25/97). Exclusion Criteria: * Patients who have a malignancy involving the hypothalamic-pituitary ax * Patients who are not treated with irradiation to the brain or spinal axis.

Locations (1)

University of Rochester, Dept. Radiation Oncology

Rochester, New York, United States

Outcomes

Primary Outcomes

Change from baseline in Cytokine blood levels

Time frame: 12 weeks from start of radiation

Data from ClinicalTrials.gov

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