Enteral Glutamine Supplementation for the Patient With Major Torso Trauma

Phase 1TerminatedNCT00178581

The University of Texas Health Science Center, Houston20 enrolled

Overview

Glutamine is considered a conditionally essential amino acid during critical illness. After severe trauma, glutamine supplementation into the gastrointestinal tract may help maintain bowel function. We hypothesize that for the major torso trauma patient, high dose glutamine given enterally during resuscitation from shock and continued during enteral nutrition support is absorbed, available systemically and preserves gut integrity.

In this prospective, randomized, controlled trial of patients with major torso trauma, high-dose enteral glutamine and enteral nutrition will be given to research subjects while controls will receive isocaloric, isonitrogenous enteral support. Enteral tolerance, bowel integrity and permeability will be evaluated. The systemic appearance of glutamine will be measured.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Trauma Critical Illness Shock

Interventions

GlutamineDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult trauma patients meeting criteria for shock resuscitation * Major torso trauma * Admission to the Shock/Trauma Intensive Care Unit Exclusion Criteria: * Age \<18 years * Pregnant * Expected survival \< 24 hours * Bowel in discontinuity * Renal failure: baseline serum creatinine\>3.0 and/or dialysis * Admission total bilirubin \>10 mg/dl * History of cirrhosis or cirrhosis apparent on exploratory laparotomy * Asystole or CPR required

Locations (1)

University of Texas Health Science Center at Houston

Houston, Texas, United States

Outcomes

Primary Outcomes

Gut function

Secondary Outcomes

Systemic appearance of glutamine

Data from ClinicalTrials.gov

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