The Effects of Nutrition Supplementation and Resistance Exercise During Hemodialysis

Vanderbilt University11 enrolled

Overview

To test the hypothesis that an exercise session combined with adequate nutritional supplementation improves skeletal muscle protein accretion during a hemodialysis session.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

End Stage Renal Disease

Interventions

nutritional supplementationDRUG

2 oral ingestions per study visit of protein supplement containing a total of 960 kilocalories: 132.8 kilocalories from protein, 412.8 kilocalories from carbohydrates, and 412.8 kilocalories from fat; 6 study visits over a 12-month period

exerciseBEHAVIORAL

resistance training on a duel leg press consisting of 3 sets of 8-12 repetitions; the first 5 study visits over a 12-month period

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * On hemodialysis for more than 3 months, on a thrice weekly hemodialysis program. * Adequately dialyzed (Kt/V \> 1.2). * Age 18-75 Exclusion Criteria: * Pregnant women. * Patients unable to perform exercise * Severe unstable underlying disease besides commonly associated with ESRD. Cardiac patients that are stable will be included. * Patients hospitalized within the last month prior to the study. * Patients with malfunctioning arterial-venous access (recirculation and/or blood flow \< 750 ml/min) * Patients receiving steroids and/or other immunosuppressive agents.

Locations (1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Outcomes

Primary Outcomes

improvement in net protein muscle balance

Time frame: 10 hours

Secondary Outcomes

improvement in net whole body protein balance

Time frame: 10 hours

Data from ClinicalTrials.gov

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