The Effects of Resistance Exercise and Protein Supplementation in Hemodialysis Patients

Vanderbilt University19 enrolled

Overview

The objective of this study is to determine how protein supplementation, with or without exercise, affects functional capacity, strength, body composition, and physical activity in hemodialysis patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

End Stage Renal Disease

Interventions

nutritional supplementationDRUG

oral administration of 2 cans of protein supplement (lactose-free formula that contains a total of 960 kilocalories: 132.8 kilocalories from protein, 412.8 kilocalories from carbohydrates, and 412.8 kilocalories from fat); every other day, 3 days per week, for 6 months

exerciseBEHAVIORAL

leg press exercise; every other day, 3 days per week, for 6 months

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * On hemodialysis for more than 3 months, on a thrice weekly hemodialysis program; * Adequately dialyzed (Kt/V ≥ 1.2). * Age ≥ 18 years old. Exclusion Criteria: * Patients unable to perform exercise due to cardiovascular disease, osteoarthritis, etc., as determined by the PI and the primary physician of the subject. * Pregnant women. * Patients hospitalized within the last month prior to the study.

Locations (1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Outcomes

Primary Outcomes

increase in lean body mass

Time frame: 12 months

Secondary Outcomes

increase in physical functioning

Time frame: 12 months

Data from ClinicalTrials.gov

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