C-Reactive Protein as a Predictor of Stem Cell Transplant Complications

Ann & Robert H Lurie Children's Hospital of Chicago70 enrolled

Overview

The purpose of this study is to determine if C-Reactive Protein levels are predictive for complications post transplant.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cancer Leukemia Stem Cell Transplantation

Interventions

C-Reactive Protein levelsBEHAVIORAL

Each patient enrolled in the study will have a serum quantitative c-reactive protein (crp) level drawn on the day of transplant, day 7 of transplant, and twice weekly after that until recovery of neutrophil count (approximately 20-25 days). Patients will be followed for 100 days post-transplant for the development of the following complications: 1. Sepsis- defined as fever, positive blood culture, need for fluid resuscitation and/or pressor support. 2. Acute GVHD \> grade II defined according to the Seattle criteria 3. VOD- defined according to the modified Seattle criteria

Eligibility

Sex: ALLMin age: 6 MonthsMax age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 6 months to 20 years * Patient undergoing a stem cell transplant (allogeneic, syngeneic, or autologous) at Childrens' Memorial Hospital * IRB approved informed consent (and assent for children age 12-17)

Locations (1)

Children's Memorial Hospital

Chicago, Illinois, United States

Outcomes

Primary Outcomes

To determine whether quantitative c-reactive protein measurements can predict major morbidity and mortality in pediatric stem cell transplant patients.

Time frame: To day +100 post transplant

Data from ClinicalTrials.gov

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