Assessment of Ventilation-perfusion Abnormalities in Patients With Stable Smoking-related Airways Disease

Imperial College London2 enrolled

Overview

Subjects undergo history, examination, lung function assessment after informed consent has been obtained. All subjects will undergo ventilation-perfusion scans. If there first scan is normal they will undergo a second and final scan four weeks later. If abnormal they will undergo two further scans with either nebulized bronchodilator or nebulized saline prior to their second and third scans. Each time they will have repeat lung function tests prior to scanning. We will examine the regional changes in ventilation and perfusion and there relationship to lung function.

As in Brief description

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

Eligibility

Sex: ALLMin age: 35 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * FEV1 \< 70% predicted at baseline on spirometry * significant smoking history or alpha 1 antitrypsin deficiency * no evidence of current infection or restrictive lung disease Exclusion Criteria: * history of other significant respiratory disease * significant respiratory infection within 6 weeks * history of significant physical or mental illness rendering them unfit for the study in the opinion of the investigator * taken part in any other research within the past 12 months, or received exposure to ionizing radiation

Outcomes

Primary Outcomes

scan grade

previously validated grading score

Time frame: post scan

Secondary Outcomes

lung function

Time frame: pre scan