Treatment of a Cancerous Disease of the Peritoneum With Complete Cytoreductive Surgery and Intraperitoneal Chemohyperthermia

Phase 2TerminatedNCT00180960

Gustave Roussy, Cancer Campus, Grand Paris100 enrolled

Overview

The purpose of this study is to evaluate the treatment of a cancerous disease of the peritoneum with complete cytoreductive surgery with intraperitoneal chemohyperthermia using oxaliplatin plus irinotecan. This is a Phase II study with 100 patients. Origins of the tumors: these include colon, rectum, appendix, peritoneum, and endocrine tumors.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Colon Tumors Rectum Tumors Appendix Tumors Peritoneum Tumors Endocrine Tumors

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Peritoneal seedings coming from colon, rectum, pseudomyxoma (appendix), peritoneum (mesothelioma and serous tumors), or endocrine tumors. * No extra-abdominal metastases * Good general status (American Society of Anesthesiologists Physical Status score \[ASA\] 1 or 2) * Signed consent Exclusion Criteria: * Tumor seedings coming from other origins * Huge peritoneal carcinomatosis (peritoneal score \> 25, except for pseudomyxomas) * Peritoneal carcinomatosis progressing rapidly * Presence of extra-abdominal metastases * Patients presenting contraindications to the use of oxaliplatin or irinotecan

Treatment of a Cancerous Disease of the Peritoneum With Complete Cytoreductive Surgery and Intraperitoneal Chemohyperthermia

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes