Pharmacokinetics of Curcumin in Healthy Volunteers

Massachusetts General Hospital6 enrolled

Overview

This study looks to describe the pharmacokinetics of curcumin delivered as a single oral dose in healthy female volunteers. The impact of piperine and silybin on the pharmacokinetics of curcumin is also studied.

Healthy volunteers are seen on three separate visits and receive 4 gm of curcumin as a single oral dose either alone or with piperine or with silybin. Serial timed blood draws then are collected for pharmacokinetic analysis.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

CurcuminDRUG

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteer * On no medications except for birth control pills * Signed informed consent Exclusion Criteria: * Pregnant * Comorbid disease

Locations (1)

Massachusetts General Hospital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Curcumin pharmacology

Secondary Outcomes

Interactions between piperine and curcumin

Interactions between silybin and curcumin

Data from ClinicalTrials.gov

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