Concerta Treatment in Adults With ADHD NOS

Inclusion Criteria: 1. Male and female outpatients older than 18 and younger than 55 years of age. 2. Subjects with the diagnosis of Attention Deficit Hyperactivity Disorder Not Otherwise Specified (ADHD NOS), by DSM-IV, as manifested in clinical evaluation and confirmed by structured interview. This is operationalized by either * Having at least 5 out of 9 current DSM-IV items of either inattention or hyperactivity/impulsivity but \< 5 items from either list in childhood * Having 5 out of 9 current DSM-IV items of either inattention or hyperactivity/impulsivity, but not having the 6 current symptoms in either category. This second category will be included independent of the presence or absence of ADHD symptoms in childhood. 3. Subjects will have a current Clinical Global Impression: ADHD score of 4 (moderately ill) or higher illness severity. 4. Patients with past history of depression, bipolar disorder, anxiety disorder (including OCD) without current disorder for \> 3 months as ascertained through structured diagnostic interview and clinical exam. 5. Subjects treated for anxiety disorders and depression who are on a stable medication regimen for at least three months, and who have a disorder specific CGI-severity score ≤ 3 (mildly ill) and who have a score on the Hamilton-Depression and Hamilton-anxiety rating scale below 15 (mild range) will be included in the study. 6. Subjects with a past history of tics but tic free for \> 1 year. 7. Subjects with past history of substance use disorders, but substance free for \> 6 months. 8. Subjects receiving non-MAOI antidepressants (e.g., SSRI's, bupropion, venlafaxine), or benzodiazepines who have been on a stable regimen for \> 3 months for any of the conditions listed above. Subjects taking SSRIs will be allowed into the study for the following reasons: * SSRIs are not known to interact with methylphenidate * Methylphenidate metabolism does not involve the hepatic P450 enzymatic system * SSRIs have extremely wide margins of safety * SSRIs and methylphenidate are combined routinely in clinical practice. 9. Subjects with mild cases of asthma and allergy will not be excluded. 10. Subjects with acid reflux syndrome will not be excluded. 11. Subjects with hypercholesterolemia will not be excluded. Exclusion Criteria: 1. Any clinically unstable psychiatric conditions including the following: acute psychosis, acute panic, acute OCD, acute mania, acute suicidality, bipolar disorder, acute substance use disorders (alcohol or drugs), acute OCD, sociopathy, criminality. 2. Any metabolic, neurological, hepatic, renal, cardiovascular, hematological, opthalmic, or endocrine disease. 3. Clinically significant abnormal baseline laboratory values which include the following: * Values larger than 20% above the upper range of the laboratory standard of a basic metabolic screen. * Exclusionary blood pressure parameters will include any values above 140 (systolic) and 90 (diastolic). * Exclusionary ECG parameters will include a QTC\> 460msec, QRS\>120 msec, and PR\>200 msec. Subjects having ECG evidence of ischemia or arrhythmia as reviewed by an independent cardiologist. 4. Mental retardation (I.Q. \<75). 5. Organic brain disorders. 6. Seizures or tics in the last year. 7. Subjects with a family history or diagnosis of Tourette's syndrome. 8. Subjects who are being treated with monoamine oxidase inhibitors, or have stopped treatment of monoamine oxidase inhibitors for less than 14 days prior to baseline visit. 9. Subjects taking coumadin anticoagulants, anticonvulsants, or tricyclic antidepressants. 10. Pregnant or nursing females. 11. Subjects with current adequate treatment for ADHD or a history of a previous adequate trial of Concerta. 12. Non English speaking subjects will not be allowed into the study for the following reasons: * The assessment instruments are not available and have not been adequately standardized in other languages * Our clinical trials facility is located in Cambridge and not in the MGH main campus without the availability of translators * Psychiatric questionnaires and evaluations are taxing and adding the complexity of a translator has the potential to make the patient experience even more exhausting.