Background: Activation of NO-synthase and vascular potassium (K) channels may play a role in the sepsis-induced attenuated sensitivity to norepinephrine. We examined whether various K channel blockers and NO-synthase inhibition could restore norepinephrine sensitivity during experimental human endotoxemia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
36
Hemodynamics
Time frame: 24 hrs after LPS administration
Markers of Inflammation
Time frame: 24 hrs after LPS administration
Cytokines
Time frame: 24 hrs after LPS administration
Markers of Renal Injury
Time frame: 24 hrs after LPS administration
Inducible NO synthase expression
Time frame: 24 hrs after LPS administration
NO-metabolites
Time frame: 24 hrs after LPS administration
Mediators of Vascular reactivity
Time frame: 24 hrs after LPS administration
Sensitivity to norepinephrine
Time frame: 24 hrs after LPS administration
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.